David Langlais

Acute and chronic diseases of inflammation are caused by uncontrolled activation of the immune system and by ineffective return to homeostasis following insult resolution. Environmental and genetic factors are contributing to immune dysregulation. On the genetic side, not only inter-individual variations are influencing the inflammatory responses, but also the epigenetic control of gene expression by transcription factors is important.

The aim of our lab is to understand the role of transcription factors in normal and pathological inflammatory responses. We use cutting-edge molecular biology and genomics methods to:

• Investigate the involvement of human genetic variations in autoimmune and chronic inflammatory diseases, with prime interest in Hashimoto’s thyroiditis
• Identify and characterize the function of transcription factors in acute and chronic inflammation
• Develop innovative antiinflammatory treatments, especially to target cerebral malaria